The actorâ€™s family say the beloved Blazing Saddles star was suffering from Alzheimerâ€™s disease-related complications.
Comedy legend Gene Wilder, who starred in Willy Wonka & the Chocolate Factory, has died at the age of 83.
The American actor, who also tickled cinema-goersÂ in Young Frankenstein, The Producers,Â Blazing Saddles, and Stir Crazy, passed away on Sunday night in Stamford, Connecticut, according to his family.
His nephew, Jordan Walker-Pearlman,Â said the film legend had been suffering from Alzheimerâ€™s disease-relatedÂ complications.
In a statement to Variety, Mr Walker-PearlmanÂ said the illness â€œnever stole his ability to recognise those that were closest to him, nor took command of hisÂ central-gentle-life affirming core personalityâ€.
He said the decision to delay disclosing his condition was because: â€œHe simply couldnâ€™t bear the idea of one less smile in theÂ world.
The frizzy-haired actor â€“ who excelled at playing neurotic characters caught up in madcap schemes â€“Â was twice Oscar nominated.
In 1969, he was up for best supporting actorÂ for his role in The Producers, a Mel Brooks comedy.
The pair were also in the runningÂ for the best adapted screenplay awardÂ for Young Frankenstein in 1975.
Wilder played Leo Bloom, a nervousÂ accountant who conspires to flee with the profits from a Broadway flop titled Springtime For Hitler.
Brooks said on Twitter: â€œGene Wilder â€“ One of the truly great talents of our time. He blessed every film we did with his magic & he blessed me with his friendship.â€
In 1971, WilderÂ assumed the mantle ofÂ Willy Wonka, one of his most beloved roles, which became a childrenâ€™s favourite
He starred in two other Brooks comedies in 1974,Â Western spoof Blazing SaddlesÂ and gothic horror parody,Â Young Frankenstein.Â Wilder co-starred with Richard Pryor in the 1976Â train-murder comedy Silver Streak.
The two paired up again in 1980 prison comedy Stir Crazy, whichÂ was another box office smash.
Wilder and Pryor also co-starred in See No Evil, Hear No Evil (1989),Â and Another You (1991).
The son of a Russian Jewish immigrant, Wilder wasÂ born Jerome Silberman in Milwaukee, Wisconsin, in 1933.
His interest in comedy began when as a six-year-old he began devising skits to keep his mother amused after she had a heart attack.
Wilder began acting classes at age 12 and continued performing during college.
In 1961, he went to Broadway.
Wilder had a small role as the hostage of gangsters in the 1967 classic Bonnie and Clyde, a year before The Producers.
He is survived by fourth wife Karen Boyer, whom he wed in 1991.
Wilderâ€™sÂ third wife Gilda Radner died in 1989 of ovarian cancer.
He was himself treated for non-Hodgkinâ€™sÂ lymphoma in 1999.